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KMID : 0829220110350020095
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Korean Journal of Oral and Maxillofacial Pathology
2011 Volume.35 No. 2 p.95 ~ p.100
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Central Granular Cell Odontogenic Tumor of the Mandible
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Yoon Hye-Jung
Choi So-Young
Hong Seong-Doo
Hong Sam-Pyo
Lee Jae-Il
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Abstract
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Central granular cell odontogenic tumor (CGCOT) is a rare benign odontogenic neoplasm, with approximately 30 cases having been reported. The pathogenesis of CGCOT as well as the designation of this lesion is controversial because of unknown histogenesis of the granular cell. We present an additional case of CGCOT involving the mandible of a 50-year-old Korean man who complained of asymptomatic swelling of the right buccal gingiva. Current lesion is microscopically characterized by densely packed polyhedral granular cells surrounding interspersed islands or strands of odontogenic epithelium. Immunohistochemically, granular cells were positive for Vimentin and CD68, and negative for cytokeratin and S-100. These features support a mesenchymal origin for the granular cells as other results previously reported.
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KEYWORD
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Central granular cell odontogenic tumor, Mandible
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